The name Mainframe has been applied to several Transformers characters
- Mainframe the Autobot Action Master from Generation One.
- Mainframe the rogue Decepticon from the Rise of the Chevy Autobots portion of the live-action movie continuity family.
- Mainframe the Autobot from the Transformers Animated continuity family.
Also, Mainframe Studios is the real-world CGI animation company that produced the Beast Wars and Beast Machines cartoons.
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